((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

Base Information

Chemical Name:((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)
CAS No.:1361146-89-5
Molecular Formula:C₅₅H₇₈O₄
Molecular Weight:803.222
Hs Code.:

Synonyms:((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

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Chemical Property of ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

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Technology Process of ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

There total 6 articles about ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 59779-75-8
diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate

: 23058-81-3
1-bromo-3,5-bis(propan-2-yl)benzene

: 1361146-89-5
((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

Guidance literature:: 1-bromo-3,5-bis(propan-2-yl)benzene; With magnesium; In tetrahydrofuran; for 0.25h; Reflux;

diethyl (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate; In tetrahydrofuran; Reflux;
DOI:10.1021/acs.orglett.9b00090

Reference yield: 89.2%

: 37031-29-1
(-)-dimethy-2,3-O-isopropylidene-L-tartrate

: 23058-81-3
1-bromo-3,5-bis(propan-2-yl)benzene

: 1361146-89-5
((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

Guidance literature:: 1-bromo-3,5-bis(propan-2-yl)benzene; With iodine; magnesium; In tetrahydrofuran; at 80 ℃; for 3h; Inert atmosphere;

(-)-dimethy-2,3-O-isopropylidene-L-tartrate; In tetrahydrofuran; at 0 - 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja4041016

Reference yield:

: 80058-84-0
4-bromo-2,6-diisopropylaniline

: 1361146-89-5
((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(bis(3,5-diisopropylphenyl)methanol)

Guidance literature:: Multi-step reaction with 2 steps

1.1: hypophosphorous acid; sodium nitrite; hydrogenchloride / 4 - 20 °C / Inert atmosphere

2.1: magnesium; iodine / tetrahydrofuran / 3 h / 80 °C / Inert atmosphere

2.2: 12 h / 0 - 80 °C / Inert atmosphere

With hydrogenchloride; iodine; hypophosphorous acid; magnesium; sodium nitrite; In tetrahydrofuran;
DOI:10.1021/ja4041016