Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate

Base Information

Chemical Name:Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate
CAS No.:129511-07-5
Molecular Formula:C₁₃H₁₄ClNO₄
Molecular Weight:283.711
Hs Code.:
DSSTox Substance ID:DTXSID601163542

Synonyms:Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate;129511-07-5;SCHEMBL7332624;HAFRYROUUMEXHM-UHFFFAOYSA-N;DTXSID601163542;Methyl4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate;Methyl 3-allyl-2-hydroxy-4-acetylamino-5-chlorobenzoate;methyl 4-acetamido-5-chloro-2-hydroxy-3-prop-2-enylbenzoate;Methyl 4-(acetylamino)-5-chloro-2-hydroxy-3-(2-propen-1-yl)benzoate

Suppliers and Price of Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:283.0611356
Heavy Atom Count:19
Complexity:361

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C(=C1CC=C)O)C(=O)OC)Cl

Technology Process of Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate

There total 4 articles about Methyl 4-acetamido-3-allyl-5-chloro-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

: 111049-87-7
methyl 4-acetylamino-2-allyloxy-5-chlorobenzoate

: 129511-07-5
methyl 3-allyl-2-hydroxy-4-acetylamino-5-chlorobenzoate

Guidance literature:: With 1-methyl-pyrrolidin-2-one; for 2h; Heating;
DOI:10.1248/cpb.46.42

Reference yield:

: 4093-28-1
methyl 4-acetamido-2-hydroxybenzoate

: 129511-07-5
methyl 3-allyl-2-hydroxy-4-acetylamino-5-chlorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95.5 percent / K₂CO₃, tetra-n-butylammonium chloride / acetonitrile / 22 h / Heating

2: 72.4 percent / NCS / dimethylformamide / 21 h / 70 °C

3: 61.5 percent / N-methylpyrrolidone / 2 h / Heating

With 1-methyl-pyrrolidin-2-one; N-chloro-succinimide; tetrabutyl-ammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.46.42

Reference yield:

: 91958-13-3
methyl 2-allyloxy-4-acetylaminobenzoate

: 129511-07-5
methyl 3-allyl-2-hydroxy-4-acetylamino-5-chlorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 72.4 percent / NCS / dimethylformamide / 21 h / 70 °C

2: 61.5 percent / N-methylpyrrolidone / 2 h / Heating

With 1-methyl-pyrrolidin-2-one; N-chloro-succinimide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.42