2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

Base Information

Chemical Name:2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide
CAS No.:150256-93-2
Molecular Formula:C₁₇H₁₆BrFN₂O₄S
Molecular Weight:443.293
Hs Code.:

Synonyms:2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

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Chemical Property of 2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

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Technology Process of 2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

There total 6 articles about 2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 150256-92-1
ethyl 2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxylate 1,1-dioxide

: 150256-93-2
2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

Guidance literature:: With ammonia; In methanol; for 4h; Ambient temperature;
DOI:10.3987/COM-94-6750

Reference yield:

: 2512-24-5
N-tert-butylbenzenesulfonamide

: 150256-93-2
2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi / 1.) THF, from 0 deg C to 5 deg C, 25 min, 2.) THF, RT, 17 min

2: 98 percent / formic acid / 20 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, 2 h

4: 100 percent / NH₃ / methanol / 4 h / Ambient temperature

With n-butyllithium; formic acid; ammonia; sodium hydride; In methanol;
DOI:10.3987/COM-94-6750

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 150256-93-2
2-<(4-bromo-2-fluorophenyl)methyl>-2,3-dihydro-3-ethoxy-1,2-benzisothiazole-3-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 - 5 °C

2: 1.) BuLi / 1.) THF, from 0 deg C to 5 deg C, 25 min, 2.) THF, RT, 17 min

3: 98 percent / formic acid / 20 h / Ambient temperature

4: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, 2 h

5: 100 percent / NH₃ / methanol / 4 h / Ambient temperature

With dmap; n-butyllithium; formic acid; ammonia; sodium hydride; triethylamine; In methanol; dichloromethane;
DOI:10.3987/COM-94-6750