1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

Base Information

• Chemical Name: 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone
• CAS No.: 344565-33-9
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 344565-33-9.mol

Synonyms:1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

Chemical Property of 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

There total 8 articles about 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl methyl ether (107-30-2) + 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene (87226-65-1) → 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone (344565-33-9)

Guidance literature:

With triethylamine; In acetonitrile; at 60 ℃; for 10h;

DOI:10.1021/ja00360a027

Reference yield:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline (53416-46-9) → 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone (344565-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

2: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

3: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

4: 1.) CH₃I, 3.) 3 N HCl

5: Et₃N / acetonitrile / 10 h / 60 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid; triethylamine; methyl iodide; In diethyl ether; acetonitrile;

DOI:10.1021/ja00360a027

Reference yield:

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline (75817-44-6) → 1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone (344565-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

2: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

3: 1.) CH₃I, 3.) 3 N HCl

4: Et₃N / acetonitrile / 10 h / 60 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid; triethylamine; methyl iodide; In acetonitrile;

DOI:10.1021/ja00360a027

upstream raw materials:

chloromethyl methyl ether

1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline

Downstream raw materials:

[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenylethynyl]-trimethyl-silane