1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

Base Information

• Chemical Name: 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene
• CAS No.: 87226-65-1
• Molecular Formula: C₁₉H₂₄O₃
• Molecular Weight: 300.398
• Mol file: 87226-65-1.mol

Synonyms:1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

Chemical Property of 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

There total 7 articles about 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline (53416-46-9) → 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene (87226-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

2: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

3: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

4: 1.) CH₃I, 3.) 3 N HCl

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid; methyl iodide; In diethyl ether;

DOI:10.1021/ja00360a027

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene (87226-65-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) SO₂Cl, 3.) NaOH / 1.) CH₂Cl₂, 0 deg C to room temperature, 10 h, 2.) room temperature, 3 h, 3.) 0.5 h

2: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

3: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

4: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

5: 1.) CH₃I, 3.) 3 N HCl

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; formic acid; sulfuryl dichloride; methyl iodide; In diethyl ether;

DOI:10.1021/ja00360a027

Reference yield:

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline (75817-44-6) → 1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene (87226-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

2: 1.) HCOOH / 1.) room temperature, 10 h, 2.) THF, room temperature, 1 h

3: 1.) CH₃I, 3.) 3 N HCl

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; formic acid; methyl iodide;

DOI:10.1021/ja00360a027

upstream raw materials:

methylmagnesium chloride

2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline

Downstream raw materials:

[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenylethynyl]-trimethyl-silane

1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone