N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Base Information

Chemical Name:N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide
CAS No.:441796-08-3
Molecular Formula:C₁₉H₁₉BrN₄O₄S
Molecular Weight:479.354
Hs Code.:

Synonyms:N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Suppliers and Price of N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

There total 10 articles about N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 441797-42-8
N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-benzyl-sulfamide

: 107-21-1
ethylene glycol

: 441796-08-3
N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Guidance literature:: With potassium tert-butylate; In 1,2-dimethoxyethane; at 95 ℃; for 24h;
DOI:10.1021/jm3009103

Reference yield:

: 706811-25-8
5-(4-bromophenyl)-4,6-dihydroxypyrimidine

: 441796-08-3
N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C

1.2: 0.33 h / Cooling with ice

2.1: dimethyl sulfoxide / 24 h / 20 °C

3.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C

With potassium tert-butylate; N,N-dimethyl-aniline; trichlorophosphate; In 1,2-dimethoxyethane; dimethyl sulfoxide;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 441796-08-3
N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C

2.2: 22 h / 20 - 31 °C

2.3: -10 °C / pH 6 - 7

3.1: sodium / methanol / 18 h / 0 - 20 °C

3.2: 4 h / 20 °C

3.3: 0.17 h

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C

4.2: 0.33 h / Cooling with ice

5.1: dimethyl sulfoxide / 24 h / 20 °C

6.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C

With thionyl chloride; potassium tert-butylate; sodium; sodium hydride; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dimethyl sulfoxide;