methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

Base Information

Chemical Name:methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate
CAS No.:150058-16-5
Molecular Formula:C₂₅H₂₄N₄O₂S
Molecular Weight:444.557
Hs Code.:

Synonyms:methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

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Chemical Property of methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

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Technology Process of methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

There total 8 articles about methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 542-85-8
Ethyl isothiocyanate

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

: 150058-16-5
methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

Guidance literature:: In ethanol; at 50 ℃; for 17h;
DOI:10.1021/jm00067a016

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 150058-16-5
methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 96 percent / ethanol / 17 h / 50 °C

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 150058-16-5
methyl 2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>-3-<3-ethyl(thioureido)>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

5: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

6: 96 percent / ethanol / 17 h / 50 °C

With hydrogenchloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; In ethanol; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016