(R)-2-(3-methoxyphenyl)propanoic acid

Base Information

Chemical Name:(R)-2-(3-methoxyphenyl)propanoic acid
CAS No.:127641-45-6
Molecular Formula:C₁₀H₁₂O₃
Molecular Weight:180.203
Hs Code.:

Synonyms:(R)-2-(3-methoxyphenyl)propanoic acid

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Chemical Property of (R)-2-(3-methoxyphenyl)propanoic acid

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Technology Process of (R)-2-(3-methoxyphenyl)propanoic acid

There total 4 articles about (R)-2-(3-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 133033-15-5
2-(3-methoxyphenyl)acrylic acid

: 127641-45-6
(R)-2-(3-methoxyphenyl)propanoic acid

Guidance literature:: With disodium hydrogen phosphite pentahydrate; phosphite dehydrogenase; water; nicotinamide adenine dinucleotide phosphate; ene-reductase 36; at 25 ℃; pH=6.75; enantioselective reaction; Enzymatic reaction;
DOI:10.1021/acs.orglett.0c02959

Reference yield:

: 64-18-6
formic acid

: 768-70-7
1-ethynyl-3-methoxybenzene

: 126374-24-1
(S)-(+)-2-(3'-methoxyphenyl)propanoic acid

: 127641-45-6
(R)-2-(3-methoxyphenyl)propanoic acid

Guidance literature:: With (S,S)-1,2-bis(tert-butylmethylphosphino)benzene; nickel(II) acetate tetrahydrate; acetic anhydride; triethylamine; In 1,4-dioxane; at 70 ℃; for 30h; Overall yield = 67 percent; Overall yield = 23.9 mg; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.202111778

Reference yield:

: 18927-05-4
methyl (3-methoxyphenyl)acetate

: 127641-45-6
(R)-2-(3-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 18 h / 50 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

3: ene-reductase 36; nicotinamide adenine dinucleotide phosphate; phosphite dehydrogenase; disodium hydrogen phosphite pentahydrate; water / 25 °C / pH 6.75 / Enzymatic reaction

With disodium hydrogen phosphite pentahydrate; phosphite dehydrogenase; water; tetra(n-butyl)ammonium hydrogensulfate; nicotinamide adenine dinucleotide phosphate; ene-reductase 36; potassium carbonate; lithium hydroxide; In tetrahydrofuran; toluene;
DOI:10.1021/acs.orglett.0c02959