[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

Base Information

Chemical Name:[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide
CAS No.:911381-13-0
Molecular Formula:C₂₉H₃₀F₃N₃O₄
Molecular Weight:541.57
Hs Code.:

Synonyms:[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

There total 4 articles about [2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-ethoxy-3-(4-{2-[2-(trifluoromethyl)-1H-benzimidazol-1-yl]ethoxy}phenyl)propanoic acid

: 20989-17-7
(2S)-2-phenylglycinol

: 911381-15-2
[2S,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

: 911381-13-0
[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃;

Reference yield:

: 911381-01-6
ethyl 2-ethoxy-3-(4-{2-[2-(trifluoromethyl)-1H-benzimidazol-1-yl]ethoxy}phenyl)propanoate

: 911381-15-2
[2S,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

: 911381-13-0
[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 0 - 20 °C

1.2: pH 4

2.1: triethylamine / dichloromethane / 5 - 20 °C

With sodium hydroxide; water; triethylamine; In ethanol; dichloromethane;

Reference yield:

: 197299-16-4
ethyl 2-ethoxy-3-(4-hydroxy-phenyl)-propionate

: 911381-15-2
[2S,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

: 911381-13-0
[2R,N(1S)]-3-{4-[2-(2-trifluoromethyl-benzoimidazol-1-yl)-ethoxy]-phenyl}-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 60 °C

3.1: sodium hydroxide; water / ethanol / 0 - 20 °C

3.2: pH 4

4.1: triethylamine / dichloromethane / 5 - 20 °C

With sodium hydroxide; water; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;