197299-16-4

Basic information

• Product Name: ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE
• Synonyms: Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate;Ethyl 2-ethoxy-3-(4-hydroxyphenyl);ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE
• CAS NO: 197299-16-4
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.29
• Mol File: 197299-16-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 367.296 °C at 760 mmHg
• Flash Point: 134.932 °C
• Appearance: /
• Density: 1.116 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.515
• PKA: 9.75±0.15(Predicted)
• CAS DataBase Reference: ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE(197299-16-4)
• EPA Substance Registry System: ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE(197299-16-4)

Safety Data

• Hazardous Substances Data: 197299-16-4(Hazardous Substances Data)

Usage

General Description

ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE is a chemical compound commonly used in the fragrance and flavor industries. It is a clear, colorless liquid with a sweet, floral odor and is often utilized as a fragrance ingredient in perfumes, soaps, and other personal care products. ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE is also known for its antioxidant properties and is used in the formulation of cosmetic products to help protect skin from oxidative damage. Additionally, it is used as a flavoring agent in food products, particularly in the confectionery and beverage industries. Overall, ETHYL 2-ETHOXY-3-(4-HYDROXYPHENYL)PROPIONATE serves as a versatile and valuable ingredient in various consumer goods.

InChI:InChI=1/C13H18O4/c1-3-16-12(13(15)17-4-2)9-10-5-7-11(14)8-6-10/h5-8,12,14H,3-4,9H2,1-2H3

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 13676-06-7 ethyl 2-ethoxy-2-(diethylphosphono)acetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 141109-83-3 ethyl 3-(4-benzyloxyphenyl)lactate 
• 62517-34-4 ethyl 2-hydroxy-3-(4-hydroxyphenyl)propionate 
• 817-95-8 ethyl 2-ethoxyethanoate 
• 223126-28-1 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester 
• 222835-03-2 3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester 
• 34006-60-5 ethyl 2-chloro-2-ethoxyacetate 
• 6065-82-3 Ethyl diethoxyacetate 

Downstream Products

• 220746-98-5 ethyl 2-ethoxy-3-[4-(2-bromoethoxy)-phenyl]propanoate 
• 719293-66-0 3-(4-dimethylthiocarbamoyloxy-phenyl)-2-ethoxy-propionic acid ethyl ester 
• 361575-81-7 ethyl 2-ethoxy-3-{[4-(4-isopropoxy-6-methoxyquinoline-3-yl)methyloxy]phenyl}propanoate 
• 352286-22-7 (E)-(S)-3-{4-[3-(4'-bromo-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionic acid ethyl ester 
• 352287-52-6 (E)-(S)-Ethyl 3{-4-[3-(4,4-Di-tert-butyl-[1,1';3',1]terphenyl-5'-yl)-allyloxy]-phenyl}-2-ethoxy-propionate 
• 222555-05-7 ethyl (2R)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 325793-65-5 (2S)-2-Ethoxy-3-(4-hydroxyphenyl)propanoic acid 
• 1056456-28-0 (S)-2-ethoxy-3-(4-((3-methylthiophen-2-yl)methoxy)phenyl)propionic acid ethyl ester 
• 1056456-04-2 (S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester 
• 1056455-43-6 (S)-2-ethoxy-3-(4-((5-(3-methoxyphenyl)-3-methylthiophen-2-yl)methoxy)phenyl)propionic acid 
• 1056456-02-0 (S)-2-ethoxy-3-(4-((5-(3-methoxyphenyl)-3-methylthiophen-2-yl)methoxy)phenyl)propionic acid ethyl ester 
• 222555-06-8 ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 222554-24-7 (+/-)-Ethyl 2-ethoxy-3-[4-[2-[4-oxo-3,4-dihydro-1,3-benzoxazin-3-yl]ethoxy]phenyl]propanoate 

Relevant articles and documents

Process development on the enantioselective enzymatic hydrolysis of S-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

A novel biocatalytic approach for the large-scale production of S-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid S-1 from its racemic ethylester rac-2 by enantioselective hydrolysis has been developed. S-1 is an important building block in the synthesis of PPARα and -γ agonists such as Ragaglitazar [NNC 61-0029 ((-)DRF2725)]. The development history comprises enzyme screening, biocatalyst and process optimization, and scale-up to pilot plant. The project was thereby highly interdisciplinary by combining biotechnology and chemistry technologies. The final process was successfully run on a 44-kg pilot scale in 43-48% yields and with high enantiomeric purities (98.4-99.6% ee).

NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.

NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.