2,6-Diamino-3-iodopyridine

Base Information

• Chemical Name: 2,6-Diamino-3-iodopyridine
• CAS No.: 856851-34-8
• Molecular Formula: C5H6 I N3
• Molecular Weight: 235.027
• Hs Code.: 2933399990
• Mol file: 856851-34-8.mol

Synonyms:Pyridine,2,6-diamino-3-iodo- (5CI); 3-Iodopyridine-2,6-diamine

Chemical Property of 2,6-Diamino-3-iodopyridine

Chemical Property:

• Melting Point: 125 °C
• Boiling Point: 363.0±42.0 °C(Predicted)
• PKA: 3.77±0.50(Predicted)
• PSA: 64.93000
• Density: 2.150±0.06 g/cm3(Predicted)
• LogP: 2.01300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

3-Iodopyridine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Iodopyridine-2,6-diamine is an intermediate in the synthesis of 3-Phenylphenazopyridine (P336120), an impurity of Phenazopyridine (P313751), an azo dye used in treatment of urinary tract infections. Used as an analgesic (urinary tract).

Technology Process of 2,6-Diamino-3-iodopyridine

There total 1 articles about 2,6-Diamino-3-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2.6-diaminopyridine (141-86-6) → 2,6-diamino-3-iodopyridine (856851-34-8)

Guidance literature:

With iodine; potassium carbonate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield: 91.0%

2,6-diamino-3-iodopyridine (856851-34-8) + 2-chloro-5-methoxyphenylboronic acid (89694-46-2) → 3-(2-chloro-5-methoxyphenyl)pyridine-2,6-diamine (1079401-92-5)

Guidance literature:

With sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In ethanol; water; toluene; at 20 ℃; Product distribution / selectivity; Heating / reflux;

Reference yield: 90.0%

2,6-diamino-3-iodopyridine (856851-34-8) + 2-trifluoromethoxyphenylboronic acid (175676-65-0) → 3-(2-(trifluoromethoxy)phenyl)pyridine-2,6-diamine (1079401-93-6)

Guidance literature:

With sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In ethanol; water; toluene; at 78 ℃; for 16h; Product distribution / selectivity;

upstream raw materials:

2.6-diaminopyridine

Downstream raw materials:

N-(6-amino-5-iodopyridin-2-yl)acetamide

6-amino-2-fluoro-3-iodopyridine

2-fluoro-6-hydroxy-3-iodopyridine

N-(6-fluoro-5-iodopyridin-2-yl)acetamide

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