(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

Base Information

Chemical Name:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate
CAS No.:1314081-56-5
Molecular Formula:C₂₁H₂₄ClNO₄S
Molecular Weight:421.945
Hs Code.:

Synonyms:(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

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Chemical Property of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

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Technology Process of (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

There total 5 articles about (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1147350-75-1,109904-27-0
2-Oxoclopidogrel

: 3282-30-2
pivaloyl chloride

: 1314081-56-5
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

Guidance literature:: 2-Oxoclopidogrel; With triethylamine; In tetrahydrofuran; for 0.166667h;

pivaloyl chloride; In tetrahydrofuran; at 0 - 25 ℃; for 4h;
DOI:10.1021/jm300038c

Reference yield: 69.0%

: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

: 135576-20-4
4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate hydrochloride

: 1314081-56-5
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

Guidance literature:: With potassium hydrogencarbonate; In acetonitrile; at 20 ℃; Inert atmosphere;

Reference yield:

: 32345-59-8
methyl (R)-2-chloromandelate

: 1314081-56-5
(S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / dichloromethane / 4 h / 0 °C

2.1: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 0.17 h

3.2: 4 h / 0 - 25 °C

With dmap; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm300038c