{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

Base Information

Chemical Name:{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid
CAS No.:1262891-96-2
Molecular Formula:C₃₄H₃₆FN₃O₅
Molecular Weight:585.675
Hs Code.:

Synonyms:{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

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Chemical Property of {(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

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Technology Process of {(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

There total 19 articles about {(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262892-02-3
(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

: 1262891-96-2
{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

Guidance literature:: (S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester; With water; lithium hydroxide; In 1,4-dioxane; at 50 ℃; for 1h;

With hydrogenchloride; In water; at 0 ℃; pH=2; Product distribution / selectivity;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1262891-96-2
{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: dichloromethane / 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / ethanol / 20 °C / 3000.3 Torr

3: 1H-imidazole / dichloromethane / 3 h / 20 °C

4: pyridine / dichloromethane; toluene / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

7: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran

With pyridine; 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; water; hydrogen; Dess-Martin periodane; 20% palladium hydroxide on carbon; In tetrahydrofuran; 2-methyl-but-2-ene; ethanol; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 477220-33-0,517866-77-2
2-[(2S)-4-benzylpiperazin-2-yl]ethanol

: 1262891-96-2
{(S)-1-tert-butoxycarbonyl-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: dichloromethane / 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / ethanol / 20 °C / 3000.3 Torr

3: 1H-imidazole / dichloromethane / 3 h / 20 °C

4: pyridine / dichloromethane; toluene / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

7: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran

With pyridine; 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; water; hydrogen; Dess-Martin periodane; 20% palladium hydroxide on carbon; In tetrahydrofuran; 2-methyl-but-2-ene; ethanol; dichloromethane; toluene; tert-butyl alcohol;