(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1262892-02-3
Molecular Formula:C₃₅H₃₈FN₃O₅
Molecular Weight:599.702
Hs Code.:

Synonyms:(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

There total 9 articles about (S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: 1262892-01-2
(S)-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

: 1262891-72-4
2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine

: 1262892-02-3
(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: phosgene; 2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine; With pyridine; In dichloromethane; toluene; at 0 - 20 ℃;

(S)-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; toluene;

Reference yield:

: 183591-29-9
(5S)-(1-benzyloxycarbonyl)-4-tert-butoxycarbonyl-5-(2-hydroxyethyl)piperazine

: 1262892-02-3
(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dipyridinium dichromate / dichloromethane / 20 °C

2: potassium carbonate / acetone / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 0.75 h / 20 °C / 3000.3 Torr

4: pyridine / dichloromethane; toluene / 0 - 20 °C

With pyridine; dipyridinium dichromate; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; acetone; toluene;

Reference yield:

: (S)-2-methoxycarbonylmethyl-piperazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

: 1262892-02-3
(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 0.75 h / 20 °C / 3000.3 Torr

2: pyridine / dichloromethane; toluene / 0 - 20 °C

With pyridine; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; toluene;