2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile

Base Information

• Chemical Name: 2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile
• CAS No.: 1012327-18-2
• Molecular Formula: C₁₇H₁₂BrNO₂S
• Molecular Weight: 374.258

Synonyms:2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile

Chemical Property of 2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile

Chemical Property:

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Technology Process of 2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile

There total 1 articles about 2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile (5434-50-4) + methyl dithiobenzoate (2168-78-7) + methyl iodide (74-88-4) → 2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile (1012327-18-2)

Guidance literature:

2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

methyl dithiobenzoate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

DOI:10.1021/ol800029c

Reference yield: 71.0%

2-(5-bromobenzo[d][1,3]dioxol-6-yl)-3-(methylthio)-3-phenylacrylonitrile (1012327-18-2) → 6-(2-phenylethynyl)benzo[d][1,3]dioxole-5-carbonitrile (1012327-34-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/ol800029c

upstream raw materials:

2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile

methyl dithiobenzoate

methyl iodide

Downstream raw materials:

6-(2-phenylethynyl)benzo[d][1,3]dioxole-5-carbonitrile

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