2168-78-7Relevant articles and documents
A novel approach for the synthesis of imidazo and triazolopyridines from dithioesters
Ramesha, Ajjahalli B.,Sandhya, Nagarakere C.,Pavan Kumar, Chottanahalli S.,Hiremath, Mahanthawamy,Mantelingu, Kempegowda,Rangappa, Kanchugarakoppal S.
, p. 7637 - 7642 (2016)
T3P-DMSO mediated desulfurative cyclization of in situ generated thioamides serves as an efficient and versatile method for the synthesis of imidazo[1,5-a]pyridines and [1,2,4]-triazolo[4,3-a]pyridines with good to excellent yields. Substrates such as 2-methylaminoquinoline and pyrazin-2-yl-methanamine also undergo the corresponding reactions at room temperature. This efficient protocol has several advantages such as mild conditions, short reaction time, operational simplicity and high yields.
Thioamide-substituted cinchona alkaloids as efficient organocatalysts for asymmetric decarboxylative reactions of MAHOs
Singjunla, Yuttapong,Pigeaux, Morgane,Laporte, Romain,Baudoux, Jér?me,Rouden, Jacques
, p. 4319 - 4320 (2018/08/24)
A new class of thioamide-substituted cinchona derivatives is reported. A convergent and practical approach was developed to insert the thioamide functional group onto the cinchonidine from readily available dithioesters. These organocatalysts were effective in asymmetric decarboxylative Mannich and protonation reactions of α-amido-substituted malonic acid half oxyesters (MAHOs), affording α,β- and α-amino acid derivatives, respectively, in good yields and stereoselectivities.
Efficient new protocol to synthesize aromatic and heteroaromatic dithioesters
Abrunhosa, Isabelle,Gulea, Mihaela,Masson, Serge
, p. 928 - 934 (2007/10/03)
A very efficient, high yielding procedure to synthesize substituted aromatic and heteroaromatic dithioesters is described. It involves the reaction between (phenylsulfonyl)methyl (hetero)aromatic derivatives and elemental sulfur in basic medium, followed by alkylation.
