metronidazole glycyl phenylalaninate hydrochloride

Base Information

• Chemical Name: metronidazole glycyl phenylalaninate hydrochloride
• CAS No.: 145615-35-6
• Molecular Formula: C₁₇H₂₁N₅O₅*ClH
• Molecular Weight: 411.845
• Mol file: 145615-35-6.mol

Synonyms:metronidazole glycyl phenylalaninate hydrochloride

Chemical Property of metronidazole glycyl phenylalaninate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of metronidazole glycyl phenylalaninate hydrochloride

There total 3 articles about metronidazole glycyl phenylalaninate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-tert-butyloxycarbonyl glycyl phenylalanine metronidazole ester → metronidazole glycyl phenylalaninate hydrochloride (145615-35-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

N-t-butyloxycarbonylglycyl-L-phenylalanine (4530-37-4) → metronidazole glycyl phenylalaninate hydrochloride (145615-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine / 24 h / Ambient temperature

2: 57 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In pyridine; dichloromethane;

Reference yield:

metronidazole (443-48-1) → metronidazole glycyl phenylalaninate hydrochloride (145615-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / pyridine / 24 h / Ambient temperature

2: 57 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In pyridine; dichloromethane;

upstream raw materials:

N-t-butyloxycarbonylglycyl-L-phenylalanine

metronidazole

Downstream raw materials:

Gly-Phe-OH

metronidazole

cyclo(Gly-Phe)

Refernces