methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

Base Information

Chemical Name:methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate
CAS No.:1372671-40-3
Molecular Formula:C₃₆H₃₆F₂N₄O₇
Molecular Weight:674.701
Hs Code.:

methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

Synonyms:methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

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Chemical Property of methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

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Technology Process of methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

There total 4 articles about methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N₁-[3-fluoro-4-[[6-methoxyl-7-(4-piperidinylmethoxyl)-4-quinolyl]oxyl]phenyl]-N₁'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide dihydrochloride

: 96-32-2
bromoacetic acid methyl ester

: 1372671-40-3
methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 929252-65-3
tert-butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

: 1372671-40-3
methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU; dmap / N,N-dimethyl-formamide / 30 - 40 °C

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 849217-48-7
((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

: 1372671-40-3
methyl 2-[4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)amino carbonyl]cyclopropane carbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxymethyl]-1-piperidyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU; dmap / N,N-dimethyl-formamide / 30 - 40 °C

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethyl acetate; N,N-dimethyl-formamide;