4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Base Information

Chemical Name:4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
CAS No.:1464151-10-7
Molecular Formula:C₂₅H₂₁FN₆O
Molecular Weight:440.48
Hs Code.:

Synonyms:4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Chemical Property of 4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

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Technology Process of 4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

There total 4 articles about 4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1464154-82-2
4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-fluorobenzoic acid

: 1464151-10-7
4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1082604-63-4
4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1464151-10-7
4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 20 - 80 °C / Inert atmosphere

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; HATU; In water; N,N-dimethyl-formamide;

Reference yield:

: 923595-49-7
6-chloro-3-iodo-imidazo[1,2-b]pyridazine

: 1464151-10-7
4-(6-(3-fluoro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 20 - 80 °C / Inert atmosphere

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; HATU; In water; N,N-dimethyl-formamide;