4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

Base Information

Chemical Name:4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine
CAS No.:1052686-58-4
Molecular Formula:C₁₁H₇BrFN₃O₂
Molecular Weight:312.098
Hs Code.:

Synonyms:4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

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Chemical Property of 4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

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Technology Process of 4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

There total 4 articles about 4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 797047-22-4
N-[4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenyl]-2,2-dimethylpropionamide

: 1052686-58-4
4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

Guidance literature:: With hydrogenchloride; In water; for 8h; Reflux;
DOI:10.1021/jm800318d

Reference yield:

: 1073354-10-5
2,2-dimethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propionamide

: 1052686-58-4
4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C

2.1: bromine; sodium acetate / acetic acid

2.3: Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium acetate; sodium carbonate; In 1,2-dimethoxyethane; water; acetic acid;
DOI:10.1016/j.bmcl.2014.03.022

Reference yield:

: 146141-10-8
N-[2-(3-fluoropyridin-2-yl)phenyl]-2,2-dimethylpropionamide

: 1052686-58-4
4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

Guidance literature:: N-[2-(3-fluoropyridin-2-yl)phenyl]-2,2-dimethylpropionamide; With bromine; sodium acetate; In acetic acid;

With sulfuric acid; nitric acid; trifluoroacetic acid;

With hydrogenchloride; In water; Reflux;
DOI:10.1016/j.bmcl.2014.03.022