2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Base Information

Chemical Name:2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.:1052686-59-5
Molecular Formula:C₁₇H₁₉BFN₃O₄
Molecular Weight:359.165
Hs Code.:

Synonyms:2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

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Chemical Property of 2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

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Technology Process of 2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

There total 4 articles about 2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1052686-58-4
4-bromo-2-(3-fluoropyridin-2-yl)-6-nitrophenylamine

: 73183-34-3
bis(pinacol)diborane

: 1052686-59-5
2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 160 ℃; for 0.2h; Microwave irradiation;
DOI:10.1021/jm800318d

Reference yield:

: 1073354-10-5
2,2-dimethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propionamide

: 1052686-59-5
2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 100 °C

2.1: bromine; sodium acetate / acetic acid

2.3: Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetic acid;
DOI:10.1016/j.bmcl.2014.03.022

Reference yield:

: 146141-10-8
N-[2-(3-fluoropyridin-2-yl)phenyl]-2,2-dimethylpropionamide

: 1052686-59-5
2-(3-fluoropyridin-2-yl)-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; sodium acetate / acetic acid

1.3: Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; sodium acetate; In 1,4-dioxane; acetic acid;
DOI:10.1016/j.bmcl.2014.03.022