(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

Base Information

Chemical Name:(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide
CAS No.:1311378-52-5
Molecular Formula:C₂₄H₁₅F₆NO
Molecular Weight:447.38
Hs Code.:

Synonyms:(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

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Chemical Property of (E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

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Technology Process of (E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

There total 4 articles about (E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311378-38-7
(E)-4-(trifluoromethyl)benzaldehyde O-[1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-yl]oxime

: 1311378-52-5
(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: C₂₄H₁₅F₆NO

Guidance literature:: With [CuCl(cod)]2; In acetonitrile; at 70 ℃; for 48h; optical yield given as %de; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol2012583

Reference yield:

: 1228682-63-0
1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-ol

: 1311378-52-5
(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: C₂₄H₁₅F₆NO

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

3: tetrahydrofuran / 2 h / 65 °C

4: [CuCl(cod)]2 / acetonitrile / 48 h / 70 °C / Inert atmosphere

With [CuCl(cod)]2; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1055/s-0031-1290819

Reference yield:

: C₂₄H₁₄F₃NO₃

: 1311378-52-5
(E)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-2,4-bis(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: C₂₄H₁₅F₆NO

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 2 h / 65 °C

3: [CuCl(cod)]2 / acetonitrile / 48 h / 70 °C / Inert atmosphere

With [CuCl(cod)]2; hydrazine hydrate; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0031-1290819