5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole
• CAS No.: 55042-88-1
• Molecular Formula: C₁₆H₁₅ClN₂
• Molecular Weight: 270.762
• Mol file: 55042-88-1.mol

Synonyms:5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole

Chemical Property of 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole

There total 5 articles about 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(E)-1-(but-1-en-3-yn-1-yl)-2-chlorobenzene (1339110-32-5) + phenylhydrazine (100-63-0) → 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole (55042-88-1)

Guidance literature:

With zinc trifluoromethanesulfonate; In toluene; at 150 ℃; for 2h; Inert atmosphere; Microwave irradiation;

DOI:10.1039/c1cc14850h

Reference yield:

2-chloro-benzaldehyde (89-98-5) → 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole (55042-88-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / 0.5 h / 0 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium t-butanolate / tetrahydrofuran / 0.33 h / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: zinc trifluoromethanesulfonate / toluene / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With manganese(IV) oxide; zinc trifluoromethanesulfonate; sodium hydride; diisobutylaluminium hydride; sodium t-butanolate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; toluene; mineral oil;

DOI:10.1039/c1cc14850h

Reference yield:

(E)-3-(2-chlorophenyl)propenal (1794-45-2,138555-57-4) → 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole (55042-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium t-butanolate / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: zinc trifluoromethanesulfonate / toluene / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

With zinc trifluoromethanesulfonate; sodium t-butanolate; In tetrahydrofuran; toluene;

DOI:10.1039/c1cc14850h

upstream raw materials:

2-Chlor-benzylidenaceton-phenylhydrazon

(E)-1-(but-1-en-3-yn-1-yl)-2-chlorobenzene

phenylhydrazine

(E)-3-(2-chlorophenyl)propenal

Downstream raw materials:

5-(2-chlorophenyl)-3-methyl-1-phenyl-1H-pyrazole