ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Chemical Name:ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate
CAS No.:1259366-65-8
Molecular Formula:C₂₉H₃₁F₂N₅O₅S
Molecular Weight:599.658
Hs Code.:

Synonyms:ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Chemical Property of ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Technology Process of ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

There total 3 articles about ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259366-64-7
ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

: 1259279-57-6
5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1259366-65-8
ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

Guidance literature:: With sodium carbonate; Pd(PPh₃)4; In dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1259278-72-2
(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone

: 1259366-65-8
ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; zinc / ethyl acetate; tetrahydrofuran

2: sodium carbonate / Pd(PPh₃)4 / dichloromethane; ethyl acetate; acetonitrile

With sodium hydrogencarbonate; sodium carbonate; zinc; Pd(PPh₃)4; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1259278-70-0
(3S)-3-[(2-chloro-5-fluoro-pyrimidin-4-yl)amino]cyclohexanol

: 1259366-65-8
ethyl 2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 20 h / 20 °C

2: zinc; chloro-trimethyl-silane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 0.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; sodium carbonate; Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane; water; acetonitrile;