ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Chemical Name:ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate
CAS No.:1259366-64-7
Molecular Formula:C₁₅H₂₁ClFN₃O₃
Molecular Weight:345.801
Hs Code.:

Synonyms:ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

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Technology Process of ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

There total 4 articles about ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259278-72-2
(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 1259366-64-7
ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

Guidance literature:: With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 1259278-72-2
(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone

: 1259366-64-7
ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)propanoate

Guidance literature:: chloro-trimethyl-silane; With zinc; In tetrahydrofuran; for 0.25h; Inert atmosphere; Reflux;

(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;