[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Base Information

Chemical Name:[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether
CAS No.:208755-94-6
Molecular Formula:C₂₇H₃₁F₂N₃O₂Si
Molecular Weight:495.644
Hs Code.:

Synonyms:[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Suppliers and Price of [(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

There total 7 articles about [(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-methanesulfonic acid (S)-3-benzyloxy-1-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-difluoro-propyl ester

: 208755-94-6
[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; Yield given;
DOI:10.1016/S0960-894X(98)00168-1

Reference yield:

: 100-39-0
benzyl bromide

: 208755-94-6
[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / NaH

2: 1.) (COCl)2, 2.) DMSO, Et₃N

3: 67 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 °C

4: 56 percent / Dowex 50-H₊ / methanol

5: 95 percent / imidazole

6: pyridine

7: NaN₃ / dimethylformamide

With pyridine; 1H-imidazole; sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; Dowex 50-H₊; sodium hydride; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00168-1

Reference yield:

: 117399-58-3
(1S)-2-(benzyloxy)-1-[(4S)-2,2-dimethyl-1,3-dioxolane-4-yl]-ethan-1-ol

: 208755-94-6
[(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, 2.) DMSO, Et₃N

2: 67 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / -78 °C

3: 56 percent / Dowex 50-H₊ / methanol

4: 95 percent / imidazole

5: pyridine

6: NaN₃ / dimethylformamide

With pyridine; 1H-imidazole; sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; Dowex 50-H₊; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00168-1