1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

Base Information

Chemical Name:1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one
CAS No.:86456-33-9
Molecular Formula:C₂₇H₃₀N₂O₅S₂
Molecular Weight:526.678
Hs Code.:

Synonyms:1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

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Technology Process of 1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

There total 8 articles about 1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 86456-29-3
1-<<2-(diethylamino)ethyl>amino>-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

: 86456-33-9
1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

Guidance literature:: With acetic acid; at 60 - 70 ℃; for 48h;
DOI:10.1021/jm00363a007

Reference yield:

: 108-37-2
1-bromo-3-chlorobenzene

: 86456-33-9
1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Cu, K₂CO₃ / dimethylformamide / 18 h / Heating

2: 1.) 50percent polyphosphoric acid / 1.) 130 deg C, 4 h, 2.) reflux, 18 h

3: 83 percent / 56percent HI / 3 h / Heating

4: 99 percent / pyridine / 1 h / Ambient temperature

5: 37 percent / 5 N aq. acetic acid / 48 h / 60 - 70 °C

With pyridine; PPA; hydrogen iodide; copper; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00363a007

Reference yield:

: 16807-37-7
5-methoxy-2-sulfanyl-benzoic acid

: 86456-33-9
1-<<2-(diethylamino)ethyl>amino>-4-(hydroxymethyl)-7-(toluenesulfonyloxy)-9H-thioxanthen-9-one

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Cu, K₂CO₃ / dimethylformamide / 18 h / Heating

2: 1.) 50percent polyphosphoric acid / 1.) 130 deg C, 4 h, 2.) reflux, 18 h

3: 83 percent / 56percent HI / 3 h / Heating

4: 99 percent / pyridine / 1 h / Ambient temperature

5: 37 percent / 5 N aq. acetic acid / 48 h / 60 - 70 °C

With pyridine; PPA; hydrogen iodide; copper; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00363a007