ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

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Chemical Name:ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate
CAS No.:1402056-46-5
Molecular Formula:C₂₅H₂₆N₄O₅
Molecular Weight:462.505
Hs Code.:

Synonyms:ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

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Chemical Property of ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

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Technology Process of ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

There total 4 articles about ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 4649-09-6
1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde

: 1402059-89-5
C₁₇H₂₂N₂O₅

: 1402056-46-5
ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: With piperidine; In ethanol; for 48h; Reflux;

Reference yield:

: 105-53-3
diethyl malonate

: 1402056-46-5
ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.12 h / Reflux

1.2: 2 h / 45 °C

2.1: ethanol / 16 h / 20 °C

3.1: piperidine / ethanol / 48 h / Reflux

With piperidine; sodium hydride; In tetrahydrofuran; ethanol; mineral oil;

Reference yield:

: 446-33-3
5-Fluoro-2-nitrotoluene

: 1402056-46-5
ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-({4-[(2-hydroxyethyl)-N-methylamino]-2-methylphenyl}amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1-methyl-pyrrolidin-2-one / 12 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C

3: ethanol / 16 h / 20 °C

4: piperidine / ethanol / 48 h / Reflux

With piperidine; palladium 10% on activated carbon; hydrogen; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol;