1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester
• CAS No.: 66041-55-2
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.269
• Mol file: 66041-55-2.mol

Synonyms:1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester

Chemical Property of 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester

There total 3 articles about 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromide (74-96-4) + tetralin-1-carboxylic acid (1914-65-4) → 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester (66041-55-2)

Guidance literature:

ethyl bromide; tetralin-1-carboxylic acid; With caesium carbonate; In acetonitrile; at 100 ℃; for 2h; Reflux;

With hydrogenchloride; In water;

Reference yield:

tetralin-1-carboxylic acid (1914-65-4) → 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester (66041-55-2)

Guidance literature:

With sulfuric acid;

Reference yield:

ethyl 1-naphthoate (3007-97-4) → ethyl 5,6,7,8-tetrahydronaphthalene-1-carboxylate (4242-17-5) + 1,2,3,4-tetrahydro-[1]naphthoic acid ethyl ester (66041-55-2)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 99.99 ℃; for 12.5h; under 11251.1 Torr; chemoselective reaction; Autoclave; Green chemistry;

DOI:10.1039/c3ra44871a

upstream raw materials:

tetralin-1-carboxylic acid

ethyl bromide

ethyl 1-naphthoate

Downstream raw materials:

7-Benzoyl-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid ethyl ester

Refernces

• 1、 -. "ALLOSTERIC BINDING COMPOUNDS". Page/Page column 20. . Retrieved 2012/04/23.