(R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one

Base Information

• Chemical Name: (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one
• CAS No.: 130718-69-3
• Molecular Formula: C₃₀H₃₈O₃S₂Si
• Molecular Weight: 538.847
• Mol file: 130718-69-3.mol

Synonyms:(R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one

Chemical Property of (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one

There total 4 articles about (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-3-hydroxy-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one (130718-67-1) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one (130718-69-3)

Guidance literature:

With 1H-imidazole; dmap; In diethyl ether; Ambient temperature;

Reference yield:

methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate (32174-38-2) → (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one (130718-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature

2: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

3: 96 percent / 1 M hydrochloric acid / acetone / 2 h

4: 88 percent / imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature

With 1H-imidazole; hydrogenchloride; dmap; n-butyllithium; In diethyl ether; acetone;

Reference yield:

methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate (130718-64-8,55000-34-5) → (R)-3-<(1',1'-dimethylethyl)dimethylsiloxy>-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one (130718-69-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

2: 96 percent / 1 M hydrochloric acid / acetone / 2 h

3: 88 percent / imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature

With 1H-imidazole; hydrogenchloride; dmap; n-butyllithium; In diethyl ether; acetone;

upstream raw materials:

(R)-3-hydroxy-3-(4-methoxyphenyl)-1,1-bis(p-tolylthio)propan-2-one

tert-butyldimethylsilyl chloride

methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate

methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate