methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

Base Information

Chemical Name:methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate
CAS No.:130718-64-8
Molecular Formula:C₁₃H₂₀O₄Si
Molecular Weight:268.385
Hs Code.:

Synonyms:methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

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Chemical Property of methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

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Technology Process of methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

There total 1 articles about methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 75-77-4
chloro-trimethyl-silane

: 32174-38-2
methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate

: 130718-64-8,55000-34-5
methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

Guidance literature:: With 1H-imidazole; dmap; In diethyl ether; Ambient temperature;

Reference yield:

: 130718-64-8,55000-34-5
methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

: 130796-31-5
(4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

2: 96 percent / 1 M hydrochloric acid / acetone / 2 h

3: 82 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

4: 4-toluenesulfonic acid / Ambient temperature

5: 73 percent / yellow mercuric oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 100 percent / Et₃N / CH₂Cl₂ / 48 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; mercury(II) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;

Reference yield:

: 130718-64-8,55000-34-5
methyl (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

: 127489-32-1
(4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) -78 deg C, 1 h

2: 96 percent / 1 M hydrochloric acid / acetone / 2 h

3: 82 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

4: 4-toluenesulfonic acid / Ambient temperature

5: 73 percent / yellow mercuric oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 100 percent / Et₃N / CH₂Cl₂ / 48 h / Ambient temperature

7: 87 percent / 1 M potassium permanganate, 5percent potassium phosphate / 2-methyl-propan-2-ol / 0.08 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; potassium phosphate; potassium permanganate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; mercury(II) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; tert-butyl alcohol;