butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester

Base Information

• Chemical Name: butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester
• CAS No.: 934503-10-3
• Molecular Formula: C₁₆H₂₀N₄O₄S
• Molecular Weight: 364.425
• Mol file: 934503-10-3.mol

Synonyms:butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester

Chemical Property of butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester

There total 3 articles about butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)cyclopropyl methyl ester (934503-08-9) → butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester (934503-10-3)

Guidance literature:

With ammonium molybdate tetrahydrate; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2007.01.007

Reference yield:

cis-(1R,2S)-1-butyryloxymethyl-2-hydroxymethylcyclopropane (133494-56-1) → butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester (934503-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 20 °C

2: 93 percent / ammonium heptamolybdate(VI) tetrahydrate; aq. hydrogen peroxide / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

With ammonium molybdate tetrahydrate; dihydrogen peroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/j.tet.2007.01.007

Reference yield:

1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-sulfonylmethyl)cyclopropyl methyl ester (934503-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h / 20 °C

2: 93 percent / ammonium heptamolybdate(VI) tetrahydrate; aq. hydrogen peroxide / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

With ammonium molybdate tetrahydrate; dihydrogen peroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/j.tet.2007.01.007

upstream raw materials:

butyric acid (1R,2S)-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)cyclopropyl methyl ester

cis-(1R,2S)-1-butyryloxymethyl-2-hydroxymethylcyclopropane

1-Phenyl-1H-tetrazole-5-thiol

Downstream raw materials:

5-(7-[(1S,2R)-2-((17R,18R)-17-methoxy-18-methylhexatriacontyl)cyclopropyl]heptylsulfonyl)-1-phenyl-1H-tetrazole

5-{7-[(1S,2R)-2-((17R,18R)-17-methoxy-18-methylhexatriacontyl)cyclopropyl]heptylsulfanyl}-1-phenyl-1H-tetrazole