6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine

Base Information

• Chemical Name: 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine
• CAS No.: 794591-70-1
• Molecular Formula: C₁₅H₉BrF₃N₃
• Molecular Weight: 368.156
• Mol file: 794591-70-1.mol

Synonyms:6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine

Chemical Property of 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine

Chemical Property:

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Technology Process of 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine

There total 1 articles about 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-1-chlorophthalazine (470484-70-9) + 4-trifluoromethylphenylamine (455-14-1) → 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine (794591-70-1)

Guidance literature:

hydrogenchloride; In 1,4-dioxane; for 1h; Heating / reflux;

Reference yield: 48.0%

3-methyl-2-(tributylstannanyl)pyridine (259807-97-1) + 6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine (794591-70-1) → 6-(3-methyl-2-pyridinyl)-N-(4-trifluoromethylphenyl)-1-phthalazinamine

Guidance literature:

With copper(l) iodide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 150 ℃; for 0.25h; Smith Microwave reactor;

Reference yield: 44.0%

6-bromo-N-(4-trifluoromethylphenyl)-1-phthalazinamine (794591-70-1) + 2-Methoxyphenylboronic acid (5720-06-9) → 6-(2-methoxyphenyl)-N-(4-trifluoromethylphenyl)-1-phthalazinamine

Guidance literature:

With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 0.25h; Smith Microwave reactor;

upstream raw materials:

6-bromo-1-chlorophthalazine

4-trifluoromethylphenylamine