1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

Base Information

Chemical Name:1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol
CAS No.:310883-98-8
Molecular Formula:C₂₁H₃₃NO₄Si
Molecular Weight:391.583
Hs Code.:

Synonyms:1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

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Chemical Property of 1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

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Technology Process of 1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

There total 3 articles about 1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 310883-97-7
4-(triisopropylsilyloxy)methyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole

: 310883-98-8
1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

Guidance literature:: With potassium osmate(VI); potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; methanesulfonamide; In water; acetone; tert-butyl alcohol; at 20 ℃; for 24h;
DOI:10.1021/ja002356g

Reference yield:

: 132629-37-9
ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate

: 310883-98-8
1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DIBAlH / CH₂Cl₂ / 3.5 h / -78 - 0 °C

2: 99 percent / imidasole; 4-(dimethylamino)-pyridine / dimethylformamide / 3 h / 20 °C

3: 99 percent / potassium osmate dihydrate; potassium ferricyanide; potassium carbonate / quinoclidine; methanesulfonamide / 2-methyl-propan-2-ol; H₂O; acetone / 24 h / 20 °C

With 1H-imidazole; dmap; potassium osmate(VI); diisobutylaluminium hydride; potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; methanesulfonamide; In dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/ja002356g

Reference yield:

: 107367-72-6
4-hydroxymethyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole

: 310883-98-8
1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / imidasole; 4-(dimethylamino)-pyridine / dimethylformamide / 3 h / 20 °C

2: 99 percent / potassium osmate dihydrate; potassium ferricyanide; potassium carbonate / quinoclidine; methanesulfonamide / 2-methyl-propan-2-ol; H₂O; acetone / 24 h / 20 °C

With 1H-imidazole; dmap; potassium osmate(VI); potassium carbonate; potassium hexacyanoferrate(III); Quinuclidine; methanesulfonamide; In water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/ja002356g