132629-37-9

Upstream product

• 1885-38-7 cinnamic nitrile 
• 14762-48-2 ethyl 2-diazo-3-oxo-propanoate 
• 591-50-4 iodobenzene 
• 460081-24-7 2-vinyloxazole-4-carboxylic acid ethyl ester 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 103-64-0 bromostyrene 
• 203116-76-1 N-[1-oxo-3-phenyl-2-(E)-propenyl]glycine ethyl ester 
• 70-23-5 ethyl Bromopyruvate 
• 100-42-5 styrene 
• 621-79-4 cinnamamide 
• 621-79-4 cinnamamide 

Downstream Products

• 181633-66-9 2-(1,2-Dihydroxy-2-phenyl-ethyl)-oxazole-4-carboxylic acid ethyl ester 
• 194232-57-0 2-((E)-Styryl)-oxazole-4-carboxylic acid amide 
• 259809-67-1 2-[(E)-2-phenylethenyl]oxazole-4-carbaldehyde 
• 181633-60-3 ethyl 2-formyl-1, 3-oxazole-4-carboxylate 
• 107367-72-6 4-hydroxymethyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole 
• 617705-26-7 2-ethynyloxazole-4-carboxylic acid ethyl ester 
• 310883-97-7 4-(triisopropylsilyloxy)methyl-2-((E)-2-phenyl-1-ethenyl)-1,3-oxazole 
• 310883-98-8 1-[(4-(triisopropylsilyloxy)methyl)(1,3-oxazol-2-yl)]-2-phenyl-ethane-1,2-diol 
• 296795-18-1 (3R)-3-hydroxy-3-(2-((E)-2-phenyl-1-ethenyl)-1,3-oxazol-4-yl)-thiopropionic acid S-tert-butyl ester 
• 296795-34-1 (3R)-3-(2-((E)-2-phenyl-1-etheny)-1,3-oxazol-4-yl)-3-(triethylsilyloxy)thiopropionic acid S-tert-butyl ester 
• 1027560-84-4 3-[2-(1,2-dihydroxy-2-phenyl-ethyl)-oxazol-4-yl]-3-triethylsilanyloxy-thiopropionic acid S-tert-butyl ester 
• 296795-41-0 (2R,6S)-2-(benzyloxymethyl)-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(triisopropylsilyloxy)methyl-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)-methyl)-tetrahydro-4H-pyran-4-one 
• 296795-25-0 N-phenyl 4-((2R,6R)-4-methylene-6-(((2R,4S,6R)-4-(triisopropylsilyloxy)-6-(2-(methanesulfonylmethyl)-1,3-oxazol-4-yl)tetrahydro-2H-pyran-2-yl)methyl)tetrahydro-2H-pyran-2-yl)but-2-ynamide 
• 296795-21-6 4-((2R,4S,6R)-6-(((7S,9R)-9-(benzyloxymethyl)-1,4,8-trioxaspiro-[4.5]dec-7-yl)methyl)-4-(triisopropylsilyloxy)tetrahydro-2H-pyran-2-yl)-2-(triisopropylsilyloxymethyl)-1,3-oxazole 

Relevant academic research and scientific papers

Preparation and reactivity of ethyl 2-vinyloxazole-4-carboxylate

The one-step synthesis of ethyl 2-vinyloxazole-4-carboxylate is described. The reactivity of this synthetically useful oxazole fragment towards addition and Heck coupling was examined.

MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES

The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy

A novel synthetic route to substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylates via C-formylation of glycine ethyl ester hydrochloride is reported. This methodology is simple, robust, and gives good yields of different heterocyclic esters in one or two steps from a common acyclic precursor and is amenable to large scale synthesis.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

A silver-mediated one-step synthesis of oxazoles

A silver-mediated one-step procedure to 2,4-disubstituted and 2,4,5-trisubstituted oxazoles has been developed. The method is complementary to existing technologies, yet provides advantages with regard to simplicity, efficiency, and performance. The silver product can be readily recycled, thus minimizing waste.

FLUORINATED AMINOTRIAZOLE DERIVATIVES

The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.