ETHYL 2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE
• CAS No.: 132629-37-9
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol file: 132629-37-9.mol

Synonyms:ethyl 2-[(E)-2-phenylethenyl]-1,3-oxazole-4-carboxylate;(E)-2-(styryl)oxazole-4-carboxylic acid ethyl ester;ethyl (2-((E)-2-phenyl-1-ethenyl)-1,3-oxazol-4-yl)formate;2-((E)-Styryl)-oxazole-4-carboxylic acid ethyl ester;ethyl 2-[(E)-styryl]oxazole-4-carboxylate;4-ethoxycarbonyl-2-(trans-styryl)oxazole;ethyl 2-cinnamyl-1,3-oxazole-4-carboxylate;

Chemical Property of ETHYL 2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE

Chemical Property:

• Melting Point: 107 - 109 °C
• Boiling Point: 393.8±45.0 °C(Predicted)
• PKA: -1.17±0.10(Predicted)
• PSA: 52.33000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 3.02170

Purity/Quality:

95%-98% ^*data from raw suppliers

ETHYL2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE

There total 11 articles about ETHYL 2-STYRYL-1,3-OXAZOLE-4-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

iodobenzene (591-50-4) + 2-vinyloxazole-4-carboxylic acid ethyl ester (460081-24-7) → ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate (132629-37-9)

Guidance literature:

In tetrahydrofuran; for 16h; Heating;

DOI:10.1081/SCC-120021990

Reference yield: 60.0%

ethyl Bromopyruvate (70-23-5) + cinnamamide (621-79-4,22031-64-7) → ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate (132629-37-9)

Guidance literature:

With silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 90 ℃; for 2h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jo1025332

Reference yield: 60.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + bromostyrene (103-64-0,1340-14-3) → (Z)-2-(styryl)oxazole-4-carboxylic acid ethyl ester (1134024-11-5) + ethyl 2-[(E)-2-phenylethenyl]oxazole-4-carboxylate (132629-37-9)

Guidance literature:

With palladium diacetate; caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 18h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/b816374j

upstream raw materials:

cinnamic nitrile

ethyl 2-diazo-3-oxo-propanoate

ethyl Bromopyruvate

cinnamamide

Downstream raw materials:

2-(1,2-Dihydroxy-2-phenyl-ethyl)-oxazole-4-carboxylic acid ethyl ester

2-((E)-Styryl)-oxazole-4-carboxylic acid amide

ethyl 2-formyl-1, 3-oxazole-4-carboxylate

2'-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4']bioxazolyl-4-carboxylic acid amide