(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

Base Information

Chemical Name:(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol
CAS No.:952685-52-8
Molecular Formula:C₃₉H₅₀N₂O₇
Molecular Weight:658.835
Hs Code.:

Synonyms:(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

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Chemical Property of (2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

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Technology Process of (2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

There total 6 articles about (2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 952685-51-7
tert-butyl (2S,3R)-1-cyclohexyl-4-(3,5-dimethoxybenzylamino)-3-hydroxybutan-2-ylcarbamate

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 952685-52-8
(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 34967-24-3
3,5-dimethoxybenzylamine

: 952685-52-8
(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / Heating / reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

Reference yield:

: 118388-73-1
(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate

: 952685-52-8
(2R,3S)-3-(tert-butoxycarbonylamino)-4-cyclohexyl-1-(N-(3,5-dimethoxybenzyl)-N-((9H)-fluoren-9-yl)methoxycarbonylamino)butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; diethyl ether / 0 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 0.75 h / 0 - 20 °C

3: sodium hydroxide / ethanol / 1 h

4: acetonitrile / Heating / reflux

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; acetonitrile;