Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate

Base Information

Chemical Name:Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate
CAS No.:163083-67-8
Molecular Formula:C₁₇H₁₄BrNO₂
Molecular Weight:344.208
Hs Code.:
DSSTox Substance ID:DTXSID701204460

Synonyms:163083-67-8;Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate;Methyl 5-bromo-1-(phenylmethyl)-1H-indole-3-carboxylate;DTXSID701204460;SY355174

Suppliers and Price of Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:343.02079
Heavy Atom Count:21
Complexity:370

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CN(C2=C1C=C(C=C2)Br)CC3=CC=CC=C3

Technology Process of Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate

There total 4 articles about Methyl 1-Benzyl-5-bromo-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 155134-26-2
1-Benzyl-1H-indole-3-carboxylic acid methyl ester

: 1-Benzyl-6-bromo-1H-indole-3-carboxylic acid methyl ester

: 163083-67-8
1-Benzyl-5-bromo-1H-indole-3-carboxylic acid methyl ester

Guidance literature:: With bromine; at 0 ℃; for 2h;

Reference yield:

: 773873-77-1
5-bromo-1H-indole-3-carboxylic acid methyl ester

: 100-39-0
benzyl bromide

: 163083-67-8
1-Benzyl-5-bromo-1H-indole-3-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2014.11.008

Reference yield:

: 942-24-5
3-methoxycarbonylindole

: 163083-67-8
1-Benzyl-5-bromo-1H-indole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / K₂CO₃ / dimethylformamide

2: 31 percent / Br₂ / 2 h / 0 °C

With bromine; potassium carbonate; In N,N-dimethyl-formamide;