N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

Base Information

Chemical Name:N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide
CAS No.:1391727-41-5
Molecular Formula:C₂₄H₂₂FNO₃S
Molecular Weight:423.508
Hs Code.:

Synonyms:N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

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Chemical Property of N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

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Technology Process of N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

There total 4 articles about N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1342891-34-2
N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]aniline

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1391727-41-5
N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.064

Reference yield:

: 54730-31-3
4-((2-methylbut-3-yn-2-yl)oxy)benzaldehyde

: 1391727-41-5
N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1-methyl-pyrrolidin-2-one / 8 h / Reflux; Inert atmosphere

2: toluene-4-sulfonic acid / dichloromethane / Reflux; Inert atmosphere

3: diisobutylaluminium hydride / toluene / Inert atmosphere

4: triethylamine / dichloromethane / Reflux; Inert atmosphere

With 1-methyl-pyrrolidin-2-one; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene; 1: Claisen cyclization;
DOI:10.1016/j.bmc.2012.04.064

Reference yield:

: 69964-40-5
6-formyl-2,2-dimethyl-2H-chromene

: 1391727-41-5
N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-4-fluoro-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane / Reflux; Inert atmosphere

2: diisobutylaluminium hydride / toluene / Inert atmosphere

3: triethylamine / dichloromethane / Reflux; Inert atmosphere

With diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2012.04.064