69964-40-5

Basic information

• Product Name: 2,2-diMethyl-2h-chroMene-6-carbaldehyde
• Synonyms: 2,2-diMethyl-2h-chroMene-6-carbaldehyde
• CAS NO: 69964-40-5
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22248
• Mol File: 69964-40-5.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-diMethyl-2h-chroMene-6-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diMethyl-2h-chroMene-6-carbaldehyde(69964-40-5)
• EPA Substance Registry System: 2,2-diMethyl-2h-chroMene-6-carbaldehyde(69964-40-5)

Safety Data

• Hazardous Substances Data: 69964-40-5(Hazardous Substances Data)

Usage

Derivative of 2H-chromene

benzopyran compound
2,2-dimethyl-2H-chromene-6-carbaldehyde is derived from the parent compound 2H-chromene, which is a type of benzopyran, a fused bicyclic compound consisting of a benzene ring and a pyran ring.

-6-carbaldehyde suffix

The suffix "-6-carbaldehyde" signifies the presence of an aldehyde functional group (a carbonyl group bonded to a hydrogen atom and an alkyl or aryl group) at the sixth carbon atom of the chromene ring in the compound.

Usage in organic synthesis and medicinal chemistry

2,2-dimethyl-2H-chromene-6-carbaldehyde is commonly used as a precursor in the preparation of various pharmaceuticals and bioactive molecules, making it a valuable building block in the synthesis of complex organic compounds.

Specific properties and applications

The specific properties and applications of 2,2-dimethyl-2H-chromene-6-carbaldehyde depend on its individual characteristics, such as reactivity and stability, as well as how it is used in combination with other chemicals in various chemical reactions and processes.

Upstream product

• 2513-25-9 2,2-dimethyl-2H-chromene 
• 93-61-8 N-methyl-N-phenylformamide 
• 33143-29-2 6-cyano-2,2-dimethylchromene 
• 87-69-4 tartaric acid 
• 74021-58-2 4-methoxymethoxy-3-(3-methyl-but-2-enyl)-benzaldehyde 
• 870-63-3 prenyl bromide 
• 78-79-5 isoprene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-44-5 p-cresol 
• 23446-57-3 2,2,6-trimethyl-3,4-dihydro-2H-chromene 
• 54730-30-2 4-hydroxy-3-C-prenylbenzaldehyde 
• 82305-04-2 6-bromo-2,2-dimethyl-2H-chromene 
• 68-12-2 N,N-dimethyl-formamide 
• 107-86-8 3,3-dimethyl acrylaldehyde 

Downstream Products

• 130236-69-0 4',6'-bisethoxymethoxy-2'-hydroxy-6'',6''-dimethyl-3',5'-di-C-prenylpyrano<2'',3'',4,3>chalcone 
• 122850-53-7 Z-Lonchocarpene 
• 103805-58-9 E-Lonchocarpene 
• 34818-56-9 anofinic acid 
• 72934-63-5 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-(2-hydroxy-4-methoxymethyloxyphenyl)-2-propen-1-one 
• 217442-54-1 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-(2-hydroxy-4,6-dimethoxymethyloxyphenyl)-2-propen-1-one 
• 217442-56-3 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-[2-hydroxy-5-(3,3-dimethylallyl)-4-methoxymethyloxyphenyl]-2-propen-1-one 
• 217442-57-4 (E)-3-(2,2-dimethyl-2H-chromen-6-yl)-1-[2-hydroxy-3,5-bis(3,3-dimethylallyl)-4-methoxymethyloxyphenyl]-2-propen-1-one 
• 1342890-41-8 (3,4-dimethoxyphenyl)-(2,2-dimethyl-2H-chromen-6-ylmethyl)amine 
• 310891-69-1 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-(propan-2-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis of new 2,2-dimethyl-2H-chromen derivatives as potential anticancer agents

The synthesis of some new heterocyclic derivatives comprising imidazothaidiazole, diaryl ketone and chromen as starting compound has been reported. The new series of chromen analogues have been synthesized. The reaction has been monitored by Thin Layer Chromatography (TLC) using suitable mobile phase. The Rf values have been compared and the melting points of derivatives determined. Further, these derivatives have been characterized and confirmed by IR,1H NMR and mass spectral (MS) studies. All the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay have been evaluated for their anticancer activity.

Butenolide derivative as well as preparation method and application thereof

The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.

Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents

The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising 2,2-dimethylbenzopyran groups and cinnamic acid groups have been synthesized. Preferential combination principles and bioisostere that improved the neuroprotective effect of the compounds were identified for this series via biological activity assay in vitro. Meanwhile, a functional reversal group of the acrylamide amide resulted in the most active compounds. Among them, BN-07 significantly improved the morphology of neurons and obviously increased cell survival rate of primary neurons induced by oxygen glucose deprivation (OGD), superior to clinically used anti-ischemic stroke drug edaravone (Eda). Overall, our findings may provide an alternative strategy for the design of novel anti-ischemic stroke agents with more potency than Eda.