3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester

Base Information

• Chemical Name: 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester
• CAS No.: 1447331-70-5
• Molecular Formula: C₂₉H₃₆N₄O₆
• Molecular Weight: 536.628
• Mol file: 1447331-70-5.mol

Synonyms:3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester

Chemical Property of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester

There total 8 articles about 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (193818-13-2) + 3-(6-amino-1-oxo-1,3-dihydroisoindol-2-yl)butyric acid methyl ester (1335100-72-5) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester (1447331-70-5)

Guidance literature:

With triethylamine; In acetonitrile; at -5 - 20 ℃;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-(1-oxo-1,3-dihydroisoindol-2-yl)butyric acid (1335100-69-0) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester (1447331-70-5)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid / water; sulfuric acid / 6 h / -5 °C

2: sulfuric acid / 3 h / Reflux

3: hydrogen; palladium on activated charcoal / methanol / 7 h / 20 °C

4: triethylamine / acetonitrile / -5 - 20 °C

With sulfuric acid; palladium on activated charcoal; hydrogen; nitric acid; triethylamine; In methanol; sulfuric acid; water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

Reference yield:

3-piperazine-4-yl-benzoic acid methyl ester (179003-08-8) → 3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid methyl ester (1447331-70-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 °C

2: sodium hydroxide / water / 6 h / 40 °C

3: triethylamine / acetonitrile / -5 - 20 °C

With triethylamine; sodium hydroxide; In water; acetonitrile;

DOI:10.1016/j.bmc.2013.05.019

upstream raw materials:

3-(1-oxo-1,3-dihydroisoindol-2-yl)butyric acid

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)butyric acid

3-piperazine-4-yl-benzoic acid methyl ester

Methyl 3-aminobenzoate

Downstream raw materials:

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}butyric acid

3-[1-oxo-6-(3-piperazinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]butyric acid chloride