(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

Base Information

Chemical Name:(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester
CAS No.:340963-46-4
Molecular Formula:C₃₇H₄₂N₂O₈Si
Molecular Weight:670.835
Hs Code.:

Synonyms:(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

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Chemical Property of (R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

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Technology Process of (R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

There total 8 articles about (R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82807-38-3
1-(2-methoxyphenyl)ethane-1,2-diol

: 340963-46-4
(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

7: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

8: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; potassium nitrate; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1021/jo015512q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 340963-46-4
(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

5: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; sodium cyanoborohydride; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo015512q

Reference yield:

: 340963-74-8
(S)-1-(2-methoxy-3-nitrophenyl)ethane-1,2-diol

: 340963-46-4
(R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

5: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; sodium cyanoborohydride; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo015512q