(2,4-di-t-butyl-6-isopropylphenyl)phosphine

Base Information

• Chemical Name: (2,4-di-t-butyl-6-isopropylphenyl)phosphine
• CAS No.: 365449-03-2
• Molecular Formula: C₁₇H₂₉P
• Molecular Weight: 264.391
• Mol file: 365449-03-2.mol

Synonyms:(2,4-di-t-butyl-6-isopropylphenyl)phosphine

Chemical Property of (2,4-di-t-butyl-6-isopropylphenyl)phosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-di-t-butyl-6-isopropylphenyl)phosphine

There total 5 articles about (2,4-di-t-butyl-6-isopropylphenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride (365449-02-1) → (2,4-di-t-butyl-6-isopropylphenyl)phosphine (365449-03-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1002/hc.1063

Reference yield:

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene (16358-73-9) → (2,4-di-t-butyl-6-isopropylphenyl)phosphine (365449-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 88 percent / PCl₃ / tetrahydrofuran; hexane / 1.5 h / 20 °C

2.1: 82 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1002/hc.1063

Reference yield:

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene (159556-96-4) → (2,4-di-t-butyl-6-isopropylphenyl)phosphine (365449-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0 °C

1.2: 95 percent / tetrahydrofuran; heptane; ethylbenzene / 24 h / 20 °C

2.1: diisobutylaluminum hydride / benzene / 4 h / 20 °C

2.2: 94 percent / H₂SO₄ / benzene

3.1: 71 percent / hydrazine monohydrate; KOH / triethylene glycol; H₂O / 6 h / 200 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 88 percent / PCl₃ / tetrahydrofuran; hexane / 1.5 h / 20 °C

5.1: 82 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; diisobutylaluminium hydride; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; water; benzene; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 3.1: Wolff-Kishner reduction;

DOI:10.1002/hc.1063

upstream raw materials:

(2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene

2-bromo-1,5-di-t-butyl-3-(1-formylethyl)benzene