(2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride

Base Information

• Chemical Name: (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride
• CAS No.: 365449-02-1
• Molecular Formula: C₁₇H₂₇Cl₂P
• Molecular Weight: 333.281
• Mol file: 365449-02-1.mol

Synonyms:(2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride

Chemical Property of (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride

There total 4 articles about (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene (16358-73-9) → (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride (365449-02-1)

Guidance literature:

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With phosphorus trichloride; In tetrahydrofuran; hexane; at 20 ℃; for 1.5h;

DOI:10.1002/hc.1063

Reference yield:

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene (159556-96-4) → (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride (365449-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0 °C

1.2: 95 percent / tetrahydrofuran; heptane; ethylbenzene / 24 h / 20 °C

2.1: diisobutylaluminum hydride / benzene / 4 h / 20 °C

2.2: 94 percent / H₂SO₄ / benzene

3.1: 71 percent / hydrazine monohydrate; KOH / triethylene glycol; H₂O / 6 h / 200 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 88 percent / PCl₃ / tetrahydrofuran; hexane / 1.5 h / 20 °C

With potassium hydroxide; n-butyllithium; diisobutylaluminium hydride; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; water; benzene; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 3.1: Wolff-Kishner reduction;

DOI:10.1002/hc.1063

Reference yield:

2-bromo-1,5-di-t-butyl-3-(1-formylethyl)benzene (365448-99-3) → (2,4-di-t-butyl-6-isopropylphenyl)phosphonous dichloride (365449-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 71 percent / hydrazine monohydrate; KOH / triethylene glycol; H₂O / 6 h / 200 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 88 percent / PCl₃ / tetrahydrofuran; hexane / 1.5 h / 20 °C

With potassium hydroxide; n-butyllithium; hydrazine hydrate; In tetrahydrofuran; hexane; water; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 1.1: Wolff-Kishner reduction;

DOI:10.1002/hc.1063

upstream raw materials:

2-bromo-1,5-di-tert-butyl-3-isopropylbenzene

2-bromo-1,5-di-t-butyl-3-(cyanomethyl)benzene

2-bromo-1,5-di-t-butyl-3-(1-formylethyl)benzene

2-bromo-1,5-di-t-butyl-3-(1-cyanoethyl)benzene

Downstream raw materials:

(2,4-di-t-butyl-6-isopropylphenyl)phosphine

C₃₀H₃₆ClP