(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

Base Information

Chemical Name:(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne
CAS No.:152170-21-3
Molecular Formula:C₃₂H₂₉NO
Molecular Weight:443.588
Hs Code.:

(2S,3S)-3-(benzyloxy)-2-<N-(diphenylmethylene)amino>-1-phenylhex-5-yne

Synonyms:(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

Chemical Property:

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Technology Process of (2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

There total 2 articles about (2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120238-42-8,131472-74-7
methyl (S)-2-(diphenylmethylideneamino)-3-phenylpropanoate

: 152170-21-3
(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) i-Bu₂AlH, i-Bu₃Al / 1.) CH₂Cl₂, toluene, from -73 deg C to -68 deg C, 2.) CH₂Cl₂, toluene, ether, a) -73 deg C, 10 h, b) from -73 deg C to 15 deg C, 4 h

2: 1.) KH / 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h

With triisobutylaluminum; potassium hydride; diisobutylaluminium hydride;

Reference yield:

: 100-39-0
benzyl bromide

: 152170-20-2
(2S,3S)-2--1-phenylhex-5-yn-3-ol

: 152170-21-3
(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

Guidance literature:: With potassium hydride; Multistep reaction; 1.) THF, 25 deg C , 2 h, 2.) THF, from 0 deg C to 25 deg C, 1 h;

Reference yield:

: 152170-21-3
(2S,3S)-3-(benzyloxy)-2--1-phenylhex-5-yne

: 125356-66-3,119463-16-0
(+)-preussin

Guidance literature:: Multi-step reaction with 6 steps

1: aq. H₂C₂O₄ / methanol; tetrahydrofuran / 3 h / 25 °C

2: 1.) CpTi(CH₃)2Cl / 1.) THF, Et₂O, 25 deg C, 2 h, 2.) THF, Et₂O, 25 deg C, 2 h

3: 2.) NaBH₃CN / 1.) CH₂Cl₂, 25 deg C, 2 h, 2.) CH₂Cl₂, MeOH, 25 deg C, 2 h

4: Mg, CH₃OH / 5 h / 25 °C

5: K, t-BuOH, HMPA / diethyl ether; toluene / 4 h / 25 °C

6: H₂ / 10percent Pd/C / ethanol / 2068.6 Torr

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chlorodimethylcyclopentadienyltitanium(IV); hydrogen; oxalic acid; sodium cyanoborohydride; magnesium; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; toluene;