ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Name:ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:1621366-73-1
Molecular Formula:C₂₀H₁₆F₂N₆O₃S
Molecular Weight:458.448
Hs Code.:

Synonyms:ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Technology Process of ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 3 articles about ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1224944-77-7
5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 1621367-84-7
5-amino-N-(3,4-difluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

: 1621366-73-1
ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; at 110 ℃; Microwave irradiation; Inert atmosphere;

Reference yield:

: 22131-51-7
5-amino-3-methyl-1,2-thiazole-4-carboxylic acid

: 1621366-73-1
ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 100 °C

1.2: 20 °C

2.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide; 1,4-dioxane / 110 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 1621366-73-1
ethyl 5-({4-[(3,4-difluorophenyl)carbamoyl]-3-methyl-1,2-thiazol-5-yl}amino)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / 100 °C

1.2: 20 °C

2.1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide; 1,4-dioxane / 110 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide;