(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

Base Information

Chemical Name:(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one
CAS No.:757977-15-4
Molecular Formula:C₂₈H₃₇NO₄Si
Molecular Weight:479.692
Hs Code.:

Synonyms:(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

Chemical Property:

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Technology Process of (3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

There total 9 articles about (3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 757977-13-2
4-(2-allyloxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

: 98-88-4
benzoyl chloride

: 757977-15-4
(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm061071x

Reference yield:

: (2-allyloxy-benzylidene)-(4-methoxy-phenyl)-amine

: 757977-15-4
(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: i-Pr₂NEt / CH₂Cl₂ / 12 h / -78 - 20 °C

2: lipase PS / aq. phosphate buffer; acetonitrile / 74 h / 20 °C / pH 7

3: aq. KOH / tetrahydrofuran / 0.25 h

4: imidazole / dimethylformamide / 8 h / 20 °C

5: aq. ceric ammonium nitrate / acetonitrile / 1.08 h / 0 °C

6: dimethylaminopyridine / CH₂Cl₂ / 1 h / 0 °C

With 1H-imidazole; dmap; potassium hydroxide; ammonium cerium(IV) nitrate; Lipase PS; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; phosphate buffer; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061071x

Reference yield:

: 941672-17-9
4-(2-allyloxy-phenyl)-3-hydroxy-1-(4-methoxy-phenyl)-azetidin-2-one

: 757977-15-4
(3R,4S)-1-benzoyl-3-O-triisopropylsilyloxy-4-(o-allyloxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 8 h / 20 °C

2: aq. ceric ammonium nitrate / acetonitrile / 1.08 h / 0 °C

3: dimethylaminopyridine / CH₂Cl₂ / 1 h / 0 °C

With 1H-imidazole; dmap; ammonium cerium(IV) nitrate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061071x