(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

Base Information

Chemical Name:(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one
CAS No.:1404575-28-5
Molecular Formula:C₂₃H₂₇BrN₂O₂
Molecular Weight:443.384
Hs Code.:

Synonyms:(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

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Chemical Property of (S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

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Technology Process of (S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

There total 9 articles about (S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1404573-81-4
(S)-4-isopropyl-1-phenyl-3-propionyltetrahydropyrimidin-2(1H)-one

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1404575-28-5
(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

Guidance literature:: (S)-4-isopropyl-1-phenyl-3-propionyltetrahydropyrimidin-2(1H)-one; With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; for 1h; Inert atmosphere;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at 20 ℃; for 1h; stereoselective reaction;
DOI:10.1021/ol302653g

Reference yield:

: 1404575-39-8
(S)-methyl 4-[2-{6-isopropyl-2-oxo-3-phenyltetrahydropyrimidin-1(2H)-yl}-2-oxoethoxy]-3,5-dimethoxybenzoate

: 1404575-28-5
(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -78 - 0 °C

1.2: 1 h / -78 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 10 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

3.2: 20 °C

4.1: lithium hexamethyldisilazane; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 1 h / -60 °C / Inert atmosphere

4.2: 1 h / 20 °C

With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1021/ol302653g

Reference yield:

: 1404573-67-6
(S)-3-(benzyl((R)-1-phenylethyl)amino)-4-methyl-N-phenylpentanamide

: 1404575-28-5
(S)-3-[(S)-3-(4-bromophenyl)-2-methylpropanoyl]-4-isopropyl-1-phenyltetrahydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol; water; acetic acid / 3 h / 20 °C / 3800.26 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

3.1: potassium carbonate / water; toluene / 1 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

4.2: 20 °C

5.1: lithium hexamethyldisilazane; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 1 h / -60 °C / Inert atmosphere

5.2: 1 h / 20 °C

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; acetic acid; toluene; mineral oil;
DOI:10.1021/ol302653g