3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Base Information

Chemical Name:3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide
CAS No.:667419-41-2
Molecular Formula:C₂₁H₃₃NO₄Si
Molecular Weight:391.583
Hs Code.:

3-{3-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-<i>N</i>-methoxy-<i>N</i>-methyl-propionamide

Synonyms:3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Suppliers and Price of 3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

There total 9 articles about 3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667419-25-2
3-formylbenzyl benzoate

: 667419-41-2
3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: (+)-diisopropyl tartrate; molecular sieves A₄ / toluene / -78 °C

1.2: toluene / -78 - 20 °C

2.1: 100 percent / imidazole / dimethylformamide / 2 h / 20 °C

3.1: potassium carbonate / methanol / 1 h / 20 °C

4.1: 3.44 g / 2-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran

5.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / cooling

5.2: 74 percent / CH₂Cl₂ / cooling

6.1: triethylamine / CH₂Cl₂ / 1 h / 20 °C

6.2: 91 percent / CH₂Cl₂ / 21 h / 20 °C

With 1H-imidazole; L-(+)-diisopropyl tartrate; 4 A molecular sieve; titanium tetrachloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2005.01.062

Reference yield:

: 667419-27-4
3-[(1S)-1-(tert-butyldimethylsilyloxy)but-3-ynyl]benzaldehyde

: 667419-41-2
3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / cooling

1.2: 74 percent / CH₂Cl₂ / cooling

2.1: triethylamine / CH₂Cl₂ / 1 h / 20 °C

2.2: 91 percent / CH₂Cl₂ / 21 h / 20 °C

With titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.tet.2005.01.062

Reference yield:

: 667419-40-1
{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-methanol

: 667419-41-2
3-{3-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-ynyl]-phenyl}-3-hydroxy-N-methoxy-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.44 g / 2-iodoxybenzoic acid / dimethylsulfoxide; tetrahydrofuran

2.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / cooling

2.2: 74 percent / CH₂Cl₂ / cooling

3.1: triethylamine / CH₂Cl₂ / 1 h / 20 °C

3.2: 91 percent / CH₂Cl₂ / 21 h / 20 °C

With titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2005.01.062