Technology Process of (+)-1D-2,5,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-myo-inositol
There total 9 articles about (+)-1D-2,5,6-tri-O-benzyl-3-O-(p-methoxybenzyl)-myo-inositol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) PTSA, 2.) pyridine / 1.) DMF, reflux
2: NaOH / methanol / Heating
3: NaH / dimethylformamide
4: aq. AcOH / Heating
5: 1.) Bu2SnO, 2.) CsF, KI / 1.) toluene, reflux, 3 h, 2.) DMF, RT, 3 h
6: 87 percent / NaH / dimethylformamide / 2 h / Ambient temperature
7: 83 percent / potassium tert-butoxide / dimethylsulfoxide / 3 h / 50 °C
8: 94 percent / HCl / acetone / 0.17 h / 50 °C
With
pyridine; hydrogenchloride; sodium hydroxide; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; acetic acid; cesium fluoride; potassium iodide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00049a011
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaH / dimethylformamide
2: aq. AcOH / Heating
3: 1.) Bu2SnO, 2.) CsF, KI / 1.) toluene, reflux, 3 h, 2.) DMF, RT, 3 h
4: 87 percent / NaH / dimethylformamide / 2 h / Ambient temperature
5: 83 percent / potassium tert-butoxide / dimethylsulfoxide / 3 h / 50 °C
6: 94 percent / HCl / acetone / 0.17 h / 50 °C
With
hydrogenchloride; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; acetic acid; cesium fluoride; potassium iodide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00049a011
- Guidance literature:
-
Multi-step reaction with 8 steps
1: NaOH / methanol / Heating
2: NaH / dimethylformamide
3: aq. AcOH / Heating
4: 1.) Bu2SnO, 2.) CsF, KI / 1.) toluene, reflux, 3 h, 2.) DMF, RT, 3 h
5: 87 percent / NaH / dimethylformamide / 2 h / Ambient temperature
6: 83 percent / potassium tert-butoxide / dimethylsulfoxide / 3 h / 50 °C
7: 94 percent / HCl / acetone / 0.17 h / 50 °C
With
hydrogenchloride; sodium hydroxide; potassium tert-butylate; sodium hydride; di(n-butyl)tin oxide; acetic acid; cesium fluoride; potassium iodide;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00049a011